Cỡ chữ: 
DAMMARANE-TYPE SAPONINS FROM GYNOSTEMA PENTAPHYLLUM AND THEIR CYTOTOXIC ACTIVITY
Phan Van Kiem, Pham Thanh Ky, Pham Thanh Huong, Than Kieu My, Pham Tuan Anh, Chu Van Minh, Nguyen Xuan Cuong, Nguyen Xuan Nhiem, Hyun Jae-Hee, Kang Hee-Kyoung, Kim Young Ho
Tóm tắt
A new dammarane-type saponin, gypenoside VN (1), and a known compound, 3b,20S,21-trihydroxydammar-24-ene 3-O-{[a-L-rhamnopyranosyl(1®2)][b-D-glucopyranosyl(1®3)]-a-L-arabinopyranosyl}-21-O-b-D-glucopyranoside (2), were isolated from the total saponin extract of the whole plants of Gynostemma pentaphyllum. Their structures were elucidated on the basis of spectroscopic and chemical methods. The two compounds exhibited significant cytotoxic activity against four human cancer cell lines, A549 (lung), HT-29 (colon), MCF-7 (breast), and SK-OV-3 (ovary), with IC50 values ranging from 20.2 ± 2.1 to 39.2 ± 3.3 mM. They were weakly active against the U937 (leukemia) cell line with IC50 values of 89.5 ± 4.1 and 93.6 ± 3.2 mM for 1 and 2, respectively. Regarding the HL-60 (acute promyelocytic leukemia) cell line, the two compounds were less active with IC50 values greater than 100 mM
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Journal of Science and Technology (Technical Universites), ISSN: 0868-3980